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[(g)14.5(e)0(n)15.7(e)0(s)17.8(.)-382.3(Im)19.3(po)14.8(rt)24.1(an)16.1(t)12.2(l)0(y)17.3(,)-382.3(th)15.1(e)12.8(s)0(e)-380.6(h)0(y)23.8(d)0(r)15.3(o)0(x)20.4(y)0(l)17.3(a)13.1(se)-374.3(en)15.7(z)13.1(y)0(m)17(e)12.7(s)-387(a)0(l)15.9(s)0(o)-370.8(d)0(e)16.1(p)0(e)17.7(n)0(d)]TJ
T*
[(up)22.6(on)-366.6(ot)22(he)15.7(r)-367.4(r)0(a)18.8(t)12.2(e-)18.6(li)18.2(mi)17.9(t)12.2(i)0(n)18.4(g)-371.1(co)16.9(f)12.2(a)0(c)20.2(t)0(o)15.7(r)0(s)17(,)-369.6(in)18.4(c)13.4(l)0(u)20.4(d)0(i)18.8(n)0(g)-361.9(i)0(r)21.1(o)0(n)-360.2(\()0(F)14.1(e)]TJ
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(2)Tj
/F7 1 Tf
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8.9663 0 0 8.9663 528.8881 353.1967 Tm
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[(\)a)367.2(n)383.3(d)]TJ
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[(a)13.1(s)0(c)18.4(o)0(r)15.5(b)14.5(at)19(e,)-268.4(a)13.1(n)0(d)-265.6(s)0(u)16.3(p)0(p)22.6(l)0(e)15.5(m)0(e)21.5(n)0(t)15.1(a)13.1(ti)15(on)-265.4(of)-262.5(ei)15.5(t)12.2(h)0(e)15.7(r)-272.6(fa)19(ct)19.2(or)-269(de)22.4(cr)19(ea)19.6(se)17.7(s)-273.2(H)0(I)16.9(F)]TJ
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[(le)21.9(ve)18.3(ls)-264.1(i)15.4(n)-275.3(c)13.4(e)0(l)15.5(l)-269.1(cu)18.3(lt)21.3(ur)16.9(e)-271.8(\()12.2(Kn)19.1(ow)14.6(l)15.4(e)0(s)-266.8(e)12.7(t)-272.4(a)13.1(l.)18.8(,)-268.5(2)0(0)20(0)0(3)19.9(\))0(.)]TJ
1.1128 -1.2203 TD
[(The)-297.1(HIF)-303.7(pathway)-307.5(is)-302(known)-306.5(to)-300.4(play)-299.7(a)-303(role)-304.1(in)-304.1(systemic)-305(car-)]TJ
-1.1128 -1.2266 TD
[(diorespiratory)-454.6(physiology)-461.9(\(Formenti)-455.8(et)-455.6(al.,)-451.5(2010;)-456.2(Semenza,)]TJ
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[(2004;)-197(Smith)-199.4(et)-202.7(al.,)-198.6(2006;)-197(Smith)-199.4(et)-202.7(al.,)-192.2(2008b\).)-201.9(It)-198.6(is)-200.9(of)-199.3(interest)-205.7(that)]TJ
T*
[(the)-288.3(HIF-regulated)-285.3(gene)-285.8(products)-288.5(VEGF)-287.2(and)-284.1(nitric)-289.1(oxide)-283.2(syn-)]TJ
T*
[(thase)-409.2(have)-414.5(both)-409.4(been)-412.3(implicated)-410(in)-411.6(AMS)-409.7(\(Tissot)-411.2(van)-414.6(Patot)]TJ
0 -1.2266 TD
[(et)-354.5(al.,)-356.6(2005;)-355(Wang)-354.1(et)-360.8(al.,)-350.3(2009;)-355(Wilson)-361.3(et)-354.5(al.,)-356.6(2009\),)-355.5(and)-353.7(that)]TJ
0 -1.2203 TD
[(ascorbate)-203.9(has)-200.2(been)-203.6(suggested)-205.8(by)-198.5(some)-203.9(authors)-205.5(to)-199.3(reduce)-206.5(AMS)]TJ
T*
[(scores)-391(at)-392(altitude)-397.5(\(Bailey)-393.7(and)-391.6(Davies,)-395(2001\).)-393.5(To)-391.5(our)-390.5(knowl-)]TJ
0 -1.2266 TD
[(edge,)-364.2(no)-366.6(previous)-365.8(study)-364.6(has)-364.6(examined)-369.4(the)-364.2(effect)-373.5(of)-363.7(iron)-364.5(on)]TJ
0 -1.2203 TD
[(AMS.)-305.1(However,)-305.7(iron)-301.2(loading)-304.7(has)-307.7(recently)-302.4(been)-304.8(shown)-309.7(to)-300.4(re-)]TJ
T*
[(verse)-432.5(hypoxia-induced)-442.1(pulmonary)-431.9(hypertension)-441.8(in)-430.5(healthy)]TJ
0 -1.2267 TD
[(volunteers)-317.6(at)-316.1(altitude)-321.6(\(Smith)-320.1(et)-316.5(al.,)-318.7(2009\).)-311.3(Pulmonary)-318.1(hyper-)]TJ
0 -1.2203 TD
[(tension)-463.7(is)-453.8(a)-461.1(major)-454.4(risk)-458.9(factor)-464.8(for)-459.2(high)-457.3(altitude)-460.7(pulmonary)]TJ
T*
[(edema)-252.8(\(HAPE;)-255.7(Gru)]TJ
8.0554 .0063 TD
()Tj
.4679 -.0063 TD
[(nig)-251.6(et)-259.6(al.,)-249.1(2000;)-253.9(Hackett)-257(and)-252.5(Roach,)-252.4(2001\),)]TJ
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[(suggesting)-283.8(that)-282(iron)-282.3(may)-279.7(have)-281.7(multiple)-283.1(benets)-284.3(at)-278.2(altitude.)]TJ
1.1128 -1.2266 TD
[(An)-162.9(im)17.9(po)21.2(rt)17.8(an)16.1(t)-177.5(a)13.1(lt)15(e)12.8(r)0(n)14.9(a)13.1(ti)21.3(ve)-171.4(ex)16.9(pl)20.4(a)13.1(n)0(a)16.1(t)12.2(io)19(n)-180.4(f)12.2(or)-167.9(ou)14.8(r)-177.7()0(n)18.9(d)0(i)25.1(n)0(g)17.5(s)-178.3(re)18.4(la)22.3(te)18.6(s)]TJ
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[(t)12.2(o)-426.4(th)15.1(e)-423.5(a)0(n)16.1(t)12.2(ic)16.2(ip)20.4(at)19(ed)-420.2(in)18.4(c)13.4(r)0(e)18.4(a)0(s)18.1(e)-423.5(in)-417.9(ce)19.8(ll)18.2(ul)20.4(ar)-417.5(fr)17.8(ee)-417.1(ra)18.8(di)18.8(ca)20.2(l)-427.2(f)0(o)15.7(r)0(m)20.7(a)13.1(ti)15(on)]TJ
T*
[(a)13.1(f)0(t)18(e)0(r)-221.9(i)0(r)21.1(o)0(n)-221.1(i)0(n)18.4(f)12.2(us)16.3(io)19(n)-231(\()12.2(Ka)16.6(k)14.6(h)0(l)18.4(o)0(n)-221.1(a)0(n)16.1(d)-224.3(Ca)19.3(ba)15(nt)21.4(ch)16.3(ik)23.7(,)-230.5(2)13.1(00)19.9(2\))19(.)-230.5(G)0(i)16.7(v)0(e)18.3(n)-224.7(th)15.1(a)13.1(t)]TJ
0 -1.2266 TD
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0 -1.2203 TD
[(wa)24.2(s)-323.8(r)0(e)18.4(c)13.4(en)15.7(t)12.2(l)0(y)-311.4(i)0(d)25.1(e)0(n)15.7(t)0(i)21.3()0(e)16.1(d)-319.1(a)13.1(s)-317.5(a)-322(r)0(i)21.1(s)0(k)-309.2(f)12.2(ac)20.2(to)15.7(r)-316.8(f)0(o)15.7(r)-316.8(AM)18.8(S)-320.9(\()12.2(Ba)16.5(i)15.4(l)0(e)15.5(y)-314.2(et)-310.2(al)15.9(.,)]TJ
T*
[(2)13.1(0)0(0)19.9(9)0(a)20(;)-255.8(Ba)22.8(il)18.2(e)12.8(y)-251(et)-247(a)13.1(l)0(.)18.8(,)-255.8(2)13.1(0)0(0)19.9(9)0(b)21.4(\))0(,)-243.7(f)0(u)17.1(r)0(t)17.8(h)0(e)22(r)-253.6(fr)17.8(e)12.8(e)-252.8(ra)18.8(di)18.8(ca)20.2(l)-250.1(p)0(r)16.9(o)0(d)19.5(u)0(c)18.3(t)0(i)21.3(o)0(n)-246.4(d)0(u)20.9(e)]TJ
0 -1.2266 TD
[(t)12.2(o)-274.7(ir)21.1(on)-265.4(se)17.8(em)21.5(s)-273.2(a)0(n)-268.5(u)0(n)20.5(l)0(i)18.2(k)14.5(el)15.5(y)-270(e)0(x)16.9(p)0(l)20.4(a)0(n)16.1(a)13.1(ti)15(on)-259.1(fo)15.7(r)-272.6(t)12.2(he)-268.8(a)13.1(p)0(p)16.3(a)13.1(re)18.4(nt)-263.1(be)14.7(ne)22(t)]TJ
0 -1.2203 TD
[(se)17.8(e)12.8(n)-351.1(in)-342(t)12.2(h)0(e)-344.7(c)13.4(ur)16.9(re)18.4(nt)-339(st)17.2(ud)20.9(y.)-342.5(H)12.7(o)0(w)20.9(e)0(v)18.3(e)0(r)18.4(,)-350.7(f)12.2(u)0(t)17.1(u)0(r)16.9(e)-347.7(st)17.2(ud)20.9(ie)15.5(s)-349.1(c)0(o)16.9(u)0(l)20.4(d)-350.8(e)12.7(x)0(-)]TJ
T*
[(a)13.1(m)0(i)17.9(n)0(e)-287.8(t)0(h)15.1(i)0(s)-283.1(p)0(o)14.8(s)0(s)22.7(i)0(b)17.3(i)0(l)18.2(i)0(t)21.3(y)-301.6(di)25.1(re)18.4(ct)19.2(ly)17.3(,)-300.1(f)12.2(or)-288(ex)16.9(a)13.1(m)0(p)13.7(l)15.4(e)-303.4(b)14.6(y)-301.6(m)15.1(ea)13.2(su)22.6(ri)21.1(ng)-292.3(f)12.2(r)0(e)18.4(e)]TJ
0 -1.2267 TD
[(ra)18.8(di)25.1(ca)13.9(l)15.4(-)0(m)14.6(e)12.8(di)18.8(at)19(ed)-515.1(li)18.2(pi)20.4(d)-521.5(p)0(e)17.7(r)0(o)15.5(x)0(i)19.6(d)0(a)22.8(t)0(i)15(o)0(n)-512(o)0(r)-515.6(o)0(t)15.7(h)0(e)22(r)-525.5(bl)23.7(oo)13.4(d-)21.8(de)16.1(ri)21.1(ve)18.3(d)]TJ
0 -1.2203 TD
[(ma)21.9(rk)20.2(er)18.4(s)-273.2(o)0(f)-256.2(o)0(x)14(i)0(d)25.1(a)0(t)19(i)0(v)14.7(e)-271.8(st)23.5(re)18.4(ss)-261.9(\(B)15.5(a)13.1(i)0(l)18.2(e)12.7(y)-270(e)0(t)-265.9(a)13.1(l.)18.8(,)-268.5(2)0(0)19.9(0)0(9)20(a)0(\))19(.)]TJ
ET
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BT
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[(FIG.)-444.3(1.)]TJ
/F5 1 Tf
4.2047 0 TD
[(Increase)-448.7(in)-449.5(Lake)-443.1(Louise)-448.2(AMS)-447.6(score)-452.9(after)-450(rapid)-444.4(ascent)-446.5(to)-452.2(high)-444.7(altitude.)-451(Prior)-445.3(to)-445.8(ascent,)-449.4(volunteers)-456.7(received)-449.6(an)]TJ
-4.2047 -1.1128 TD
[(intravenous)-352.2(infusion)-342.2(of)-344.7(either)-349.3(iron\(III\)-hydroxide)-350.8(sucrose)-348.1(\(200)-169.7(mg)-343.4(in)-342(100)-169.3(mL;)]TJ
/F6 1 Tf
34.4472 0 TD
(n)Tj
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[(12\))-340.9(or)-344.9(saline)-346.3(placebo)-345.9(\(100)-169.7(mL)-342(over)-345.6(30)-163.4(min;)]TJ
/F6 1 Tf
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[(12\).)-261.7(Within)-259.9(2)-170.2(h)-262.6(of)-256.2(the)-263(infusion,)-262.9(volunteers)-267(began)-264.5(the)-256.7(ascent)-263.1(by)-261.8(road)-258.9(to)-262.5(Cerro)-263.5(de)-255.8(Pasco)-263.5(\(4340)-169.2(m\),)-260.2(which)-264.1(took)-257(approximately)]TJ
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51.3104 0 TD
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(SEM\).)Tj
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[(*indicates)-337.1(signicant)-338(difference)-339.3(between)-338.4(groups)-334.4(\()]TJ
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[(IRON)-334.7(SUPPLEMENTATION)-342.1(AND)-337.2(ACUTE)-334.5(MOUNTAIN)-334.9(SICKNESS)-22823(267)]TJ
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